SLC22A12 and hypouricemia, renal: The regulation of urate excretion, especially by a cluster of urate transporters in the kidneys, is important in the homeostasis of SUA [48], which has been corroborated by the presence of type I and type II renal hypouricemia caused by SLC22A12 [49,50,51] and SLC2A9 dysfunction [32,52], respectively.