CCR2 and ischemia: During hepatic ischemia/reperfusion (I/R) injury in mice, accumulation of CD11b+Ly-6Chigh monocytes (M-MDSCs) recruited by the C-C motif chemokine ligand 2 (CCL2)/C-C chemokine receptor 2 (CCR2) axis accelerates liver inflammation, which can be suppressed by CCR2 inhibitor RS504393 and depletion of CCL2 or CCR2 [41].