In mice with subcutaneous xenograft HCC (human liver cancer cell lines such as HepG2, Huh-7, and MHCC97H), curcumin treatment can inhibit the frequency of CD11b+GR-1+ MDSCs and suppress the expression of G-CSF and GM-CSF by suppressing the TLR4/NF-κB signaling pathway [60]. This evidence concerns the gene CSF2 and hepatocellular carcinoma.