Another study also reveals that lectin-type oxidized LDL receptor-1 (LOX-1)+CD15+ PMN-MDSCs, which can suppress T cell proliferation and IFN-γ production by producing reactive oxygen species (ROS) and arginase 1 [54], are negatively associated with the overall survival of HCC patients. This evidence concerns the gene ARG1 and hepatocellular carcinoma.