NFKB1 and hepatocellular carcinoma: Activation of the NF-κB signaling pathway can also promote the invasion of HCC cells by regulating extracellular matrix (ECM) remodeling, the expression of degradation enzyme matrix metalloproteinases (MMPs), and epithelial–mesenchymal transition (EMT), as well as angiogenesis in the tumor microenvironment [75].