Furthermore, T cells expressing immune checkpoint proteins, including T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), CTLA4, Lymphocyte activation gene 3 (LAG3), and PD-1, were less prevalent in ALK+ NSCLC than in EGFR/KRAS + NSCLC. This evidence concerns the gene LAG3 and non-small cell lung carcinoma.