The cutoff values for CFS were 55.8 μg/L for P1NP (sensitivity, 73.1%; specificity, 87.8%; and AUC, 0.85) and 400 mU/dL for TRACP-5b (sensitivity, 57.7%; specificity, 87.8%; and AUC, 0.78) (Figure 2). The gene discussed is ACP5; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.