The current report aimed to analyze the patterns of association and the role of incretins, muscle functionality, and body composition in women with cancer compared with healthy women (mammography BI-RADS I or II), trying to elucidate whether GIP and GLP-1 can estimate the risk, in conjunction with overweight or obesity, for breast cancer. Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.