UBE2E3 and Parkinson disease: In present work, using automatic image analysis and super resolution microscopy, we studied the parameters of the MN in fibroblasts from patients with established hereditary PD, associated with the following: (1) mutations in the PINK1 gene, encoding PTEN-induced kinase 1; (2) simultaneous mutations in genes PINK1 and PARK2, encoding PINK1 and Parkin RBR E3 ubiquitin protein ligase; (3) A53T point mutation in SNCA gene, encoding α-synuclein; (4) G2019S mutation in LRRK2 gene, encoding leucine-rich repeat kinase 2 protein.