Large B-cell lymphomas with a MYC rearrangement, along with B-cell lymphoma 2 (BCL2) and/or B-cell lymphoma 6 (BCL6) rearrangements, are being classified as high-grade B-cell lymphomas (HGBLs) and are frequently referred to as double-hit (DHL) and triple-hit lymphomas (THL), respectively. The gene discussed is BCL2; the disease is B-cell non-Hodgkin lymphoma.