Patients were divided into four therapeutic groups for the purpose of the analyses—Group A, which received R-CHOP (or R-mini-CHOP in older patients); Group B, which received R-CHOP with intermediate-dose methotrexate (0.5 g/m2); Group C, which received R-DA-EPOCH; and Group D, which received a therapeutic regimen without anthracyclines (the reasons being pre-existing cardiac comorbidity, previous anthracycline exposure and exceeded cumulative dose, or relapsed disease where DEL/DHL was diagnosed at relapse and not as the first lymphoma diagnosis). Here, DDIT3 is linked to lymphoma.