Moreover, left-atrial blood stasis is linked with higher risk of left-atrial appendage thrombus (LAAT) and stroke in AF patients, while vWF is linked to thromboembolism in AF, and the thrombogenic activity of vWF is proportional to multimer size, which is regulated by vWF-cleaving protease (ADAMTS13). Here, ADAMTS13 is linked to atrial fibrillation.