Recent work [16] showed that NOTCH-1 has a key role in maintaining TNBCSC stemness; in fact, NOTCH-1 receptor expression and activation strongly correlate with the aggressive clinicopathological and biological phenotypes of breast cancer (e.g., invasiveness and chemoresistance), which are relevant characteristics of the TNBC subtype. The gene discussed is NOTCH1; the disease is breast carcinoma.