This review analyzed 19 in vitro and 5 in vivo studies, indicating that curcumin decreased glioblastoma cell proliferation and viability by acting on multiple pathways inducing a decrease in prosurvival proteins such as NF-kB, AP-1, and PI3K, as well as upregulating proteins involved in apoptotic pathways such as p21, p53, and caspase 3 [11]. Here, TP53 is linked to glioblastoma.