The ability of curcumin to directly bind and inhibit several cellular proteins, such as proinflammatory COX and lipoxygenase, proliferation-inducing PKC, Src, Erb2, anti-apoptotic Bcl2, and pro-angiogenic P-12-LOX, which play a role in different types of malignant cells, might explain the broad antitumor action of curcumin described for different types of cancers [14,59]. The gene discussed is BCL2; the disease is cancer.