Liver cancers (LIHC and Cholangiocarcinoma (CHOL)) had a higher probability of occurring disulfidoptosis compared to adjacent noncancerous tissues because their oxidative stress response genes NDUFS1 and mitochondrial gene NUBPL were downregulated and pro-cuproptosis genes SLC7A11 were upregulated in cancer tissues. The gene discussed is SLC7A11; the disease is cholangiocarcinoma.