Liver cancers (LIHC and Cholangiocarcinoma (CHOL)) had a higher probability of occurring disulfidoptosis compared to adjacent noncancerous tissues because their oxidative stress response genes NDUFS1 and mitochondrial gene NUBPL were downregulated and pro-cuproptosis genes SLC7A11 were upregulated in cancer tissues. This evidence concerns the gene NDUFS1 and liver cancer.