Orecchioni et al. [38,39] have shown GO functionalized with amino functional groups did not disrupt cellular homeostasis and induced activation of genes that were crucial for the cross-talk between innate and adaptive response, such as CCL3 and CCL5, or transcription factors of the Th1 response (STAT1) that were central to tumor suppression and elimination [40]. Here, CCL5 is linked to neoplasm.