Enriched in tissues with high energy demands, PGC-1α is involved in the pathogenesis of obesity and its comorbidities, and perturbed PGC-1α expression is found in lots of tissues, like adipose tissue, liver, skeletal muscle, and brain, both in human obese subjects and HFD-induced obese animal models [36,52,53,54,55,56,57,58]. This evidence concerns the gene PPARGC1A and Obesity.