APP and Alzheimer disease: Interestingly, in different AD models, it has been shown that the transcription of the genes encoding amyloid-β precursor protein (APP) and β-Site APP cleaving enzyme 1 (BACE1), that play a key role in the deposition and aggregation of extracellular Aβ, is upregulated by the activation of ROS-sensitive HSF-1 and NF-kb transcription factors or by the activity of stress-activated protein kinase.