PD animal models generated by the treatment with complex I inhibitors displayed potentiated NLRP3 inflammasome activation, ASC speck formation, and pro-IL-1β processing to IL-1β, thus suggesting that NLRP3 inflammasome signalling could be induced by mitochondria damage and contribute to the dopaminergic neurodegenerative process [169]. The gene discussed is NLRP3; the disease is Parkinson disease.