In an early report concerning neurological diseases, PGRMC1 induced proliferation of neural progenitor cells, regulated neurogenesis and synapse remodeling [34,35], inhibited TNF-α induction of gene expression in neural cells [36], and had neuroprotective effects in neonatal hypoxic–ischemic brain injury [37], related to brain-derived neurotrophic factor (BDNF) signaling [38,39]. This evidence concerns the gene BDNF and nervous system disorder.