SOD1 and hearing loss disorder: Furthermore, several mouse lines, which were deficient for antioxidant components, such as superoxide dismutase 1 (SOD1) [700], glutathione peroxidase 1(GPX1) [700], plasma membrane calcium ATPase 2(PMCA2) [739] or Cadherin Related 23 (CDH23) [740] showed also increased sensitivity to noise-induced hearing loss.