NOX3 and hearing loss disorder: Building up on their previous findings, which showed a connection between TVRP1-mediated Ca2+ influx and Nox3-mediated ROS [541], as well as noise-induced Nox3-derived ROS production in rat cochleae [741], the group of Mukerjeah and colleagues further investigated the complex interplay of Ca2+, ROS and pro-inflammatory cytokines during noise-induced hearing loss [655].