In addition, metabolomic analysis of plasma from HLT participants or patients with AD suggested that the lipidomic profile of individuals with higher TNF-α levels was mostly associated with alterations in the triglyceride profile, whereas the increase in Aβ42 and decrease in MMSE scores correlated better with alterations in phosphatidylcholine and lysophosphatylcholine patterns [21]. Here, TNF is linked to Alzheimer disease.