Similarly, in adenocarcinoma human alveolar basal epithelial cells (A549) and colon carcinoma cells (HCT-116/R), NADPH oxidase isoform (NOX) 2 and Nrf2 were associated with the development of drug resistance due to the stimulation of MDR1 expression, and they may be potential targets for overcoming drug resistance during cancer therapy [167,168]. Here, ABCB1 is linked to colon carcinoma.