In another study on a human colon carcinoma cell line (Caco-2), a decrease in the content of microRNA-145 increased the expression and activity of Pgp, but not the amount of mRNA of the MDR1 gene, indicating that, in this cell line, microRNA-145 regulates Pgp through translational mRNA repression [89]. This evidence concerns the gene ABCB1 and colon carcinoma.