PLIN1 and Immunodeficiency: More recently, a dual role of Plin1 has been described in modulating the immune deficiency signaling in the fat body of the fruit fly, Drosophila melanogaster. Plin1 was shown to be downregulated in the early stages of the immune response, leading to the formation of large LDs and thereby taking part in an antioxidative function, efficiently eliminating ROS accumulation after bacterial infection [9].