Proteins and enzymes that have been involved in the regulation of ferroptosis in HCC include Nrf2, S1R (Sigma-1 receptor), HSPB1 (heat shock protein beta-1), p53, and YAP/TAZ (Yes-Associated Protein/Transcriptional Co-Activator With PDZ-Binding Motif), e.g., mostly influencing resistance to or the negative regulation of ferroptosis [93]. This evidence concerns the gene HSPB1 and hepatocellular carcinoma.