Since the PI3K/AKT signaling pathway promotes protein synthesis, cell survival, proliferation, and migration [5,6], PTEN dysfunction can contribute to the development of certain hereditary tumorigenesis disorders such as Cowden syndrome, Proteus syndrome, Bannayan–Riley–Ruvalcaba syndrome, and Lhermitte–Duclos disease [7], as well as various cancers including breast [8], thyroid [9], endometrium [10], prostate [11], brain [12], and skin cancer [13]. The gene discussed is PTEN; the disease is cancer.