NFKB1 and cholestasis: RA, which was identified as one of the most abundant polyphenolic compounds in Glechoma hederacea, also demonstrated protective effects against cholestasis-related liver injury via the attenuation of oxidative stress and the downregulation of HMGB1/TLR4, NF-κB, AP-1, and TGF-β1/SMAD signaling [67].