In precision medicine, pathophysiological mechanisms involved in the pathogenesis of obesity-related hypertension, such as leptin resistance, impaired baroreceptor and chemoreceptor reflexes, increased renal sympathetic nervous activity, mitochondrial dysfunction, and the regulatory role of intermedin and adrenomedullin, can be the focus of specific and selective therapeutic interventions [81]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.