Although we did not list that SREBF1 and TXNIP genes were promising to be our primary candidate DNA regions in our ongoing study, the pathophysiological role of SREBF1 and TXNIP genes in IR and T2DM was discussed here to provide comprehensive knowledge as their hydroxymethylation related to T2DM was investigated by Zampieri et al. [22]. Here, SREBF1 is linked to type 2 diabetes mellitus.