SOCS3 and type 2 diabetes mellitus: For the specific CpG site in gene SOCS3, the analyses of methylation-sensitive PCR data showed significantly high 5hmC levels in SOCS3 CpG 16 in high PAR T2DM patients vs. low PAR T2DM and controls separately (Dunn-Bonferroni test p ≤ 0.01 for both).