Given the lack of statistical significance for differential hydroxymethylation in the study by Zampieri et al. [22] and the relative small sample size in our ongoing study, without consideration of the pathophysiological role of SREBF1 and TXNIP genes in IR and T2DM [34,35], we identified the DNA region related to the SOCS3 gene as a promising primary candidate DNA region for future investigation of its hydroxymethylation in blood associated with incident T2DM. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.