CRP and insomnia: These findings were further corroborated by another study on cancer survivors, which found that the patients displayed fatigue and insomnia symptoms four years after diagnosis; moreover, fatigue and insomnia were associated with high levels of C-Reactive Protein, one of the main inflammatory biomarkers, suggesting that the long-term pro-inflammatory cytokine cascade elicited by the disease might remain elevated over time and chronically disrupt sleep [40,41].