The results of flow cytometry analysis showed that compared with the model group, 20.4 g/kg of SCPE treatment (HD group) and FMTS significantly downregulated the proportion of CD4+T and CD8+T lymphocytes in the peripheral blood (PB) and spleen (SP) of colitis mice (p < 0.05), although DSS administration induced marked upregulation of them. The gene discussed is CD4; the disease is colitis.