For instance, the complex composed of ACID, JIP1, and JNK1, the complex composed of JIP1 and JNK1/2/3, and the complex composed of Sab and JNK1/2/3 are also involved in JNK signaling transduction and are critical for neurodegenerative diseases, autoimmune inflammatory diseases/glomerulosclerosis, and non-alcoholic steatohepatitis, respectively. The gene discussed is MAPK8; the disease is neurodegenerative disease.