Of course, the question arises if (i) the increased heme biosynthesis, (ii) TCA cycle impairment due to succinyl-CoA depletion with a consequent reduction in GTP and acetyl-CoA, and (iii) combined Arg/Cit/His decreases are also relevant for the impact of CLPP antagonist drugs on the growth of bacteria and cancer cells. The gene discussed is CLPP; the disease is cancer.