ABCG2 and cancer: Cryo-electron microscopy (cryo-EM) has been instrumental in providing three-dimensional (3D) structural insights into MDR-causing ABC transporters like ABCB1, ABCC1, ABCC3, ABCC4, and ABCG2, shedding light on protein-ligand interactions and opening avenues for effective modulator development to combat drug resistance in cancer [11].