SIRT1 and obesity due to melanocortin 4 receptor deficiency: By interfering with AMPK, sirtuin 1 (SIRT1), proliferator-activated-receptor-gamma-coactivator-1, catechol-O-methyltransferase, and sympathetic nervous system, which are key players in the transcriptional regulation and physiology of AT, phenolic compounds such as curcumin, quercetin, resveratrol, and isoflavones play crucial roles in thermogenesis and consequently lowering obesity [80].