For example, among adult women with breast cancer, childhood maltreatment has been associated with greater transcriptional activity of the nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB] [18,19,20] and the interferon regulatory factors (IRF) [19], suggesting a pattern of exaggerated immune activation and propensity for proinflammatory signaling. The gene discussed is TRIM63; the disease is breast carcinoma.