After adjusting for MDD, adolescents exposed to maltreatment showed bioinformatic indications of increased IRF activity [V$IRF1_01: mean 1.72-fold asymmetry (SE = 1.29), p = 0.04] and decreased NF-κB activity [V$NFKAPPAB_01: mean 0.66-fold asymmetry (SE = 1.18), p = 0.01]. The gene discussed is NFKB1; the disease is major depressive disorder.