KDR and neoplasm: During tumor neovascularization, VEGFR2 mediates endothelial cell proliferation, migration, and invasion, acting as a major cellular signaling transducer that facilitates the phosphorylation of protein kinase B (Akt), extracellular signal-regulated kinase 1 and 2 (Erk 1 and 2), mammalian target of rapamycin (mTOR), and focal adhesion kinase (FAK) and also the activation of the downstream signaling mediated by them [4,11].