Likewise, a reduction in PD-1+ among T17-like and T1/17-like CD4+CD8+ T cells in the OB vs. nOB group (p < 0.05), more marked in Class III obesity, IRn, and Pre-T2D for the T17-like cells (p < 0.05) and in Class IV for the T1/17-like CD4+CD8+ T cells (p < 0.05), was observed (Supplementary Table S9). Here, CD4 is linked to obesity due to melanocortin 4 receptor deficiency.