Moreover, participants with Class II obesity displayed an increase in the percentage of T17-like CD4+CD8+ Tf cells compared to nOB, while in the remaining groups, T17-like cells tended to be decreased (nOB: 15% ± 14.5; OBII: 20% ± 12.3; OBIII: 11% ± 9.5; OBIV: 6.9% ± 3.8; OBII vs. OBIV, p < 0.05; Supplementary Table S9). Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.