In similarity to T17-like cells, T1/17-like CD4+CD8+ Tf cells were also reduced in participants with Class III obesity (nOB: 10 ± 9.1, OBII: 13% ± 7.7, OBIII: 6.9% ± 5.1, OBIV: 12% ± 5.4; OBIII vs. OBIV, p < 0.05) and in the IRn group (6.8% ± 5.7, p > 0.05 vs. nOB; Supplementary Table S9). This evidence concerns the gene TF and obesity due to melanocortin 4 receptor deficiency.