In similarity to the Tfh, the Tfc also display higher expression of CXCR5 in OB (p < 0.05; Supplementary Table S8), particularly in Class II obesity, as well as a higher percentage of activated Tfc cells (OB: 10% ± 5.3 vs. nOB: 6.6% ± 4.0, p < 0.05; Figure 13B and Supplementary Table S8). This evidence concerns the gene CXCR5 and obesity due to melanocortin 4 receptor deficiency.