PON2 and atherosclerosis: In this context, PON2 enzyme activity was able to reduce the overwhelming levels of ROS production and release associated with the onset and progression of atherosclerosis, a vascular disorder characterized by biochemical events leading to severe ER stress and the activation of the unfolded protein response (UPR) pathway, which, in turn, may induce activation of the apoptotic executioner caspase-3.