Pathogenic variants in other NADPH oxidases were shown to increase susceptibility to inflammatory bowel disease (NOX1 and DUOX2, [60]), or cause congenital hypothyroidism (DUOX2, Thyroid dyshormonogenesis 6, AR, [61]; DUOXA2, Thyroid dyshormonogenesis 5, AR, [62], Table 1). Here, FMO5 is linked to familial thyroid dyshormonogenesis.