STAT3 and leukemia: Another study found that in HL60 leukemia cells, TQ-mediated activation of apoptosis and reduced cell proliferation were linked to the downregulation of essential elements of the JAK/STAT (such as JAK2, STAT3, p-STAT3, STAT5, and p-STAT5) and PI3K/AKT (such as PI3K, p-PI3K, AKT, and p-AKT,) signaling pathways [64].