However, in the CARDIOTOX (CARDIOvascular TOXicity induced by cancer-related therapies) registry, which enrolled 855 patients treated with different types of therapy, including radiation therapy (RT), both NT-proBNP and cTn elevations at baseline were not associated with the development of severe CTRCD identified as LVEF < 40% or clinical HF [114]. The gene discussed is NPPB; the disease is hydrops fetalis.