The HFA-ICOS risk score takes into consideration lifestyle risk factors, demographic and CV risk factors, previous CV diseases, previous and concomitant cardiotoxic cancer treatment and baseline cardiac biomarkers (elevated baseline troponin—Tn, elevated baseline brain natriuretic peptide—BNP or NT-proBNP) in patients receiving six of the most frequently used anticancer treatments [80]. The gene discussed is NPPB; the disease is cancer.