ZBTB20 and neoplasm: For example, depletion of ZBTB20 in Huh7 human hepatocytes increases the percentage of hepatitis C virus (HCV)-infected cells and HCV production, indicating that ZBTB20 suppresses HCV infection [75], whereas in HCC patients with chronic infection of hepatitis B virus (HBV), HBV DNA integrates into ZBTB20, which is upregulated in tumor tissues and associated with HBV integration frequency [87].