PIK3CA and neoplasm: For example, FAK is able to trigger via the integrin-FAK-Src signal transduction pathway the activation of serine/threonine-protein kinase (AKT), β-catenin (Wnt signaling pathway), cyclin D1, ERK (Ras-ERK signaling pathway), JNK (RhoA-JNK pathway), phosphatidylinositol-3-kinase (PI3K), and other proteins, whereas tumor suppressing genes like phosphatase and tensin homolog (PTEN) and glycogen synthase kinase 3α/β (GSK3α/β) are blocked [213,214].