CAV1 and neoplasm: It is important to note nonetheless that Cav1 also acts as a tumor suppressor by helping E-cadherin in the sequestration of β-catenin, thereby impairing the β-catenin/Tcf-Lef-dependent transcriptional activation of genes encompassing survivin, cyclooxygenase-2, cyclin D1, and multiple other proteins fostering the development of cancer [45,46].