SFRP4 and hydrops fetalis: We then identified captopril (targeting BNC2), aldosterone (targeting MEOX2), cyclopenthiazide (targeting MEOX2), estradiol (targeting COL14A1), tolazoline (targeting COL14A1), and genistein (targeting SFRP4) previously have been reported to treat or alleviate HF [64,65,66,67,68,69], as candidate therapeutic agents for HF.