A positive correlation between OGN and NT-proBNP (R = 0.95, p = 0.0036) is shown in Figure 10C. Leveraging GSE135055 as an external validation cohort, we noted that in comparison with the control, the expressions of plasma OGN in patients with HF also significantly increased (Figure 10D). The gene discussed is OGN; the disease is hydrops fetalis.