The results demonstrated that COL14A1, OGN, MFAP4, and SFRP4 achieved AUC scores all larger than 0.85 in the training cohort (Figure 5A and Figure S5A) and test cohort (Figure 5D and Figure S5B), suggesting the high sensitivity and specificity that distinguish HF from control. The gene discussed is COL14A1; the disease is hydrops fetalis.