We subsequently compared the diagnostic performance of these four hub genes with current HF biomarkers, including myocardial stress/injury-related (model 1; BNP, NT-proBNP, TnT, TnI), neurohormone-related (model 2; MR-proADM, AVP, Peptide), myocardial remodeling-related (model 3; sST2, Gal-3, MMP, GDF-15), inflammatory-related (model 4; CRP, IL-6, TNF-α, PCT), and renal function injury-related (model 5; Cys C, NGAL) biomarkers. The gene discussed is LCN2; the disease is hydrops fetalis.