MFAP4 and hydrops fetalis: Taken together, we uncovered a comprehensive mechanism of hub genes involved in HF, which was a compact regulatory interaction of TFs–hub genes–pathways: The up-regulations of TFs (BNC2 and MEOX2) activate the transcriptions of four hub genes (COL14A1, OGN, MFAP4, SFRP4) and subsequently drive the activation or suppression of downstream signaling pathways (Figure 11).