Microfibril-associated glycoprotein 4 (MFAP4) has been proven to regulate calcium-dependent cell adhesion or intercellular interactions, leading to inflammation and fibrosis, which was previously verified to engage in remodeling-related diseases such as liver fibrosis, atherosclerosis, and arterial injury stimulated remodeling [83,84]. Here, MFAP4 is linked to Hepatic fibrosis.