IL1B and histiocytic sarcoma: The immunopathogenesis of HS is only partially elucidated and seems to clearly differ from prototypic autoimmune dermatoses, simultaneously showing characteristics of an auto-inflammatory disease (inflammasome-driven dominance of interleukin-1β (IL-1β)), the presence of a possible involvement of B cells, and a contribution of Th1 or Th17 cell subsets [3].