Other polygenic autoinflammatory syndromes that include HS, with a documented role for IL-1, are PAPASH (pyoderma gangrenosum, acne, pyogenic sterile arthritis, and HS) and PASS (pyoderma gangrenosum, acne vulgaris, ankylosing spondylitis, and HS) [44]. Here, IL1A is linked to pyoderma gangrenosum.