In addition to binding to CaM, a number of these receptors and channels bind to toxic protein biomarkers (Aβ; Tau; Htt; aSyn) linked to specific neurodegenerative diseases: mGluR5 (Aβ; αSyn), NMDAR (Aβ), PMCA (Aβ; Tau), VGCC (Aβ; Htt), TRPC (Aβ), Orai (Aβ), NCX (Aβ), VDAC (Aβ; Tau; Htt; αSyn), IP3R (Aβ; Htt), RyR (Htt) [17,18,22,24,27,28,29,30,31,32,33,34,35,36,37,38]. The gene discussed is GRM5; the disease is neurodegenerative disease.