The usual suspects have been implicated in the disruption of calcium signaling in AD, including those in the cell membrane (e.g., mGluR, NCX, NMDAR, VGCC, and TRPC), ER (IP3R and RyR), and mitochondria (PTP), but not all studies are in agreement as to the relative contributions of each one [46]. The gene discussed is RYR2; the disease is Alzheimer disease.