In a model of endotoxin-induced uveitis, an intravenous administration of α-MSH resulted in a dose-dependent reduction in the number of infiltrating cells in the anterior chamber, along with a significant reduction in tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), nitric oxide (NO), macrophage inhibitory protein 2, and monocyte chemoattractant protein 1 (MCP-1) in the aqueous humor [29]. Here, TNF is linked to uveitis.