Although trends of higher tumor cellularity associated with higher VAFs were seen in EGFR variants from the NSCLC-FNA specimens (Figure 2A) and KRAS variants from the CRC-FFPE specimens (Figure 3A), the general observation shows a poor or even no correlation between the VAF and specimen’s tumor cellularity regardless of the gene origins or specimen types. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.