MAPT and Alzheimer disease: Tau pathology has been modelled using postnatal organotypic brain slices from various TG models (3xTg-AD, JNPL3, TauRDΔK and hTau), showing increased levels of phosphorylated tau and thioflavin-S positive tau inclusions from 1 to 4 weeks in culture and redistribution of tau to the somatodendritic compartments [28,29,30,31,32].