Of note, several experimental validated target mRNAs of these two miRNAs were also dysregulated in intestine samples of HSCR patients and were related to the pathophysiology of this disease, such as ATP2A2, CSE1L, LRP8 and THBS4 (target of hsa-miR-142-3p) and CDH2 and PKM (target of hsa-miR-338-3p). This evidence concerns the gene LRP8 and Hirschsprung disease.