In another study, in a rabbit model, the preservation of the Na+/K+ pump function, upon β3-AR stimulation, promoted the reduction of congestive cardiac remodeling, which was induced by coronary ligation [109], a phenomenon observed in a diabetic heart model, where the stimulation of β3-AR prevented the Na+/K+ pump inactivation [110]. The gene discussed is ADRB3; the disease is diabetes mellitus.