Binding of circST6GALNAC6 to the N-terminus of small HSPB1 was disclosed to retard the phosphorylation of Ser-15 site of HSPB1 induced by erastin, resulting in activation of p38 MAPK pathway and subsequent enhancement of cell ferroptosis in bladder cancer [36]. The gene discussed is HSPB1; the disease is urinary bladder carcinoma.