CircPVT1 stabilized ESR1 expression, activated estrogen/ERα-target genes via adsorbing miR-181a-2-3p, and suppressed the type I IFN signaling pathway along with anti-tumor immunity through interacting with MAVS protein and disrupting the generation of RIGI-MAVS complex, thereby boosting ERα-positive BC cell growth and tamoxifen resistance [94]. This evidence concerns the gene MAVS and breast cancer.