AKT1 and breast cancer: Interestingly, endoplasmic reticulum stress induced the secretion of tumor exosomes enriched with circ_0001142, which inhibited autophagy and strengthened M2 polarization of macrophages to boost tumor proliferation and metastasis in BC through sponging miR-361-3p to enhance PIK3CB expression to induce the activation of PI3K/AKT pathway [82].