NFKB1 and neoplasm: In terms of mechanism, tumor exosomal cSERPINE2 released into the tumor immune microenvironment (TIME) was internalized by tumor associated macrophages (TAMs) and induced the secretion of IL-6 in TAMs through sponging miR-513a-5p to upregulate MALT1 expression to activate the NF-κB pathway, ultimately boosting BC cell proliferation and invasion [79].