IL18 and type 1 diabetes mellitus: Finally, IL-18 has a controversial role because the IL-18 gene-promoter polymorphisms might be associated with susceptibility to T1DM in Egyptian children [18] and with T1DM age onset [29]; however, at the same time, according to Campos L. P. et al. [26], IL-18 polymorphisms were not associated with T1DM onset in children or adults in this population.