The time of onset of hypoglycaemia, its correlation with the type of meals, and the presence of dysmorphic features are essential because HH is a heterogenous disorder that is divided into a transient form related to perinatal stress or following gastrointestinal procedures, and a congenital, monogenic HH form related to variants in fifteen genes implicated in pancreatic development and function (due to a genetic defect, insulin release is independent from the glucose level) and associated with other syndromes (such as Beckwith–Wiedemann syndrome) [21,22]. Here, INS is linked to Hypoglycemia.